Technology

The InCal™ Technology platform is using the intrathecal route for modifying intracranial pressure, cerebrospinal fluid turnover and glymphatic flow in neurodegenerative disorders, with a primary focus on glaucoma. It will use a patient friendly device that will allow continuous monitoring and adjustment of the intracranial pressure and cerebrospinal fluid circulation in patients suffering from neurodegenerative diseases.

Additionally, the medical device will allow administration of drugs in a slow release manner that will be particularly beneficial in these kind of diseases.

Selected publications

  • Wostyn P, Audenaert K, De Deyn PP. Alzheimer’s disease and glaucoma: Is there a causal relationship? Br J Ophthalmol 2009;93:1557-1559.
  • Wostyn P, De Groot V, Van Dam D, Audenaert K, De Deyn PP. Senescent changes in cerebrospinal fluid circulatory physiology and their role in the pathogenesis of normal-tension glaucoma. Am J Ophthalmol 2013;156:5-14.
  • Wostyn P, Van Dam D, Audenaert K, Killer HE, De Deyn PP, De Groot V. A new glaucoma hypothesis: a role of glymphatic system dysfunction. Fluids Barriers CNS 2015;12:16.
  • Wostyn P, De Groot V, Van Dam D, Audenaert K, Killer HE, De Deyn PP. Fast circulation of cerebrospinal fluid: an alternative perspective on the protective role of high intracranial pressure in ocular hypertension. Clin Exp Optom 2016;99:213-218.
  • Wostyn P, De Groot V, Van Dam D, Audenaert K, Killer HE, De Deyn PP. Alzheimer’s disease and glaucoma: can glymphatic system dysfunction underlie their comorbidity? Acta Ophthalmol 2017;95:e244-e245.
  • Wostyn P, De Groot V, Van Dam D, Audenaert K, Killer HE, De Deyn PP. Age-related macular degeneration, glaucoma and Alzheimer’s disease: amyloidogenic diseases with the same glymphatic background? Cell Mol Life Sci 2016;73:4299-4301.
  • Wostyn P, De Groot V, Van Dam D, Audenaert K, De Deyn PP, Killer HE. The glymphatic system: a new player in ocular diseases? Invest Ophthalmol Vis Sci 2016;57:5426-5427.
  • Wostyn P, Killer HE, De Deyn PP. Glymphatic stasis at the site of the lamina cribrosa as a potential mechanism underlying open-angle glaucoma. Clin Exp Ophthalmol 2017;45:539-547.
  • Wostyn P, De Deyn PP. Intracranial pressure-induced optic nerve sheath response as a predictive biomarker for optic disc edema in astronauts. Biomark Med 2017;11:1003-1008.
  • Wostyn P, De Deyn PP. Optic nerve sheath distention as a protective mechanism against the visual impairment and intracranial pressure syndrome in astronauts. Invest Ophthalmol Vis Sci 2017;58:4601-4602.
  • Wostyn P, De Groot V, Van Dam D, Audenaert K, Killer HE, De Deyn PP. The glymphatic hypothesis of glaucoma: a unifying concept incorporating vascular, biomechanical, and biochemical aspects of the disease. Biomed Res Int 2017;2017:5123148.
  • Wostyn P, Killer HE, De Deyn PP. Why a one-way ticket to Mars may result in a one-way directional glymphatic flow to the eye. J Neuroophthalmol 2017;37:462-463.
  • Wostyn P, De Deyn PP. Why space flight-associated neuro-ocular syndrome may differ from idiopathic intracranial hypertension. JAMA Ophthalmol 2018;136:451-452.
  • Wostyn P, De Groot V, Van Dam D, Audenaert K, De Deyn PP, Killer HE. The first histologic evidence of a paravascular pathway within the optic nerve. Invest Ophthalmol Vis Sci 2018;59:1717.
  • Wostyn P, De Deyn PP. The “ocular glymphatic system”: an important missing piece in the puzzle of optic disc edema in astronauts? Invest Ophthalmol Vis Sci 2018;59:2090-2091.
  • Wostyn P, Van Dam D, De Deyn PP. Intracranial pressure and glaucoma: Is there a new therapeutic perspective on the horizon? Med Hypotheses 2018;118:98-102.
  • Wostyn P, De Winne F, Stern C, De Deyn PP. Dilated prelaminar paravascular spaces as a possible mechanism for optic disc edema in astronauts. Aerosp Med Hum Perform 2018;89:1089-1091.
  • Wostyn P, Van Dam D, De Deyn PP. Intrathecal cerebrospinal fluid infusion as a potential therapeutic strategy for Alzheimer’s disease. Med Hypotheses 2019;122:57.
  • Wostyn P, Van Dam D, De Deyn PP. Alzheimer’s disease and glaucoma: Look-alike neurodegenerative diseases. Alzheimers Dement 2019;15:600-601.
  • Wostyn P, Mader TH, Gibson CR, Killer HE. The escape of retrobulbar cerebrospinal fluid in the astronaut’s eye: mission impossible? Eye (Lond) 2019
  • Wostyn P, Mader TH, Gibson CR, Wuyts FL, Van Ombergen A, Zu Eulenburg P, De Deyn PP. The possible role of elastic properties of the brain and optic nerve sheath in the development of spaceflight-associated neuro-ocular syndrome. AJNR Am J Neuroradiol 2020.
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